Publications

2007

N.L. Daly, Y.K. Chen, K.J. Rosengren, U.C. Marx, M.L. Phillips, A.J. Waring, W. Wang, R.I. Lehrer, D.J. Craik. (2007) Retrocyclin-2: Structural Analysis of a Potent Anti-HIV theta-Defensin.Biochemistry 46: 9920-9928.

K. Vitzithum, T. Lauber, P. Kreutzmann, A. Schulz, C.P. Sommerhoff, P. Rösch, U.C. Marx. LEKTI Domain 15 is a Functional Kazal-Type Proteinase Inhibitor, Protein Expression and Purification In Press, Accepted Manuscript.

2005

T. Egelrud, M. Brattsand, P. Kreutzmann, M. Walden, K. Vitzithum, U.C. Marx, W.G. Forssmann, H.J. Mägert. (2005) hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6. Br J Dermatol 153: 1200-1203.

T. Lauber, U.C. Marx. (2005) Prosequence-mediated disulfide coupled folding of the peptide hormones guanylin and uroguanylin. Protein Pept Lett 12: 153-158.

A. Schulz, U.C. Marx, N. Tidten, T. Lauber, Y. Hidaka, K. Adermann. (2005) Side chain contributions to the interconversion of the topological isomers of guanylin-like peptides. J Pept Sci 11: 319-330.

U.C. Marx, N.L. Daly, D.J. Craik. (2005) NMR of conotoxins: structural features and an analysis of chemical shifts of post-translationally modified amino acids. Magn Reson Chem 44: S41-50.

2004

A. Jayakumar, Y. Kang, K. Mitsudo, Y. Henderson, M.J. Frederick, M. Wang, A.K. El-Naggar, U.C. Marx, K. Briggs, G.L. Clayman. (2004) Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A. Protein Expr Purif 35: 93-101.

T. Lauber, A. Schulz, P. Rösch, and U.C. Marx. (2004) Role of disulfide bonds for the structure and folding of proguanylin. Biochemistry 43: 10050-10057.

H. Tidow, T. Lauber, K. Vitzithum, C.P. Sommerhoff, P. Rösch, U.C. Marx. (2004) The solution structure of a chimeric LEKTI domain reveals a chameleon sequence.Biochemistry 43: 11238-11247.

2003

T. Lauber, P. Neudecker, P. Rösch, U.C. Marx.(2003) Solution structure of human proguanylin: the role of a hormone prosequence. J Biol Chem 278: 24118-24124.

T. Lauber, A. Schulz, K. Schweimer, K. Adermann, U.C. Marx. (2003) Homologous proteins with different folds: the three-dimensional structures of domains 1 and 6 of the multiple Kazal-type inhibitor LEKTI. J Mol Biol 328: 205-219.

U.C. Marx, M.L. Korsinczky, H.J. Schirra, A. Jones, B. Condie, L. Otvos, Jr., D.J. Craik. (2003) Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide. J Biol Chem 278: 21782-21789.

J. Ziegler, H. Sticht, U.C. Marx, W. Muller, P. Rösch, S. Schwarzinger. (2003) CD and NMR studies of prion protein (PrP) helix 1. Novel implications for its role in the PrPC-->PrPSc conversion process. J Biol Chem 278: 50175-50181.

2002

T. Lauber, A. Nourse, A. Schulz, U.C. Marx. (2002) Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution. Biochemistry 41: 14602-14612.

2001

T. Lauber, U.C. Marx, A. Schulz, P. Kreutzmann, P. Rösch, S. Hoffmann. (2001) Accurate disulfide formation in Escherichia coli: overexpression and characterization of the first domain (HF6478) of the multiple Kazal-type inhibitor LEKTI. Protein Expr Purif 22: 108-112.

2000

U.C. Marx, K. Adermann, P. Bayer, W.G. Forssmann, P. Rösch. (2000) Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem Biophys Res Commun 267: 213-220.

S. Urban, C. Schwarz, U.C. Marx, H. Zentgraf, H. Schaller, G. Multhaup. (2000) Receptor recognition by a hepatitis B virus reveals a novel mode of high affinity virus-receptor interaction. Embo J 19: 1217-1227.

1999

A. Schulz, U.C. Marx, Y. Hidaka, Y. Shimonishi, P. Rösch, W.G. Forssmann, K. Adermann. (1999) Role of the prosequence of guanylin. Protein Sci 8: 1850-1859.

M. Weidler, U.C. Marx, G. Seidel, W. Schäfer, E. Hoffmann, A. Esswein, P. Rösch. (1999) The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution. FEBS Lett 444: 239-244.

1998

U.C. Marx, K. Adermann, P. Bayer, M. Meyer, W.G. Forssmann, P. Rösch. (1998) Structure-activity relation of NH2-terminal human parathyroid hormone fragments. J Biol Chem 273: 4308-4316.

U.C. Marx, J. Klodt, M. Meyer, H. Gerlach, P. Rösch, W.G. Forssmann, K. Adermann. (1998) One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers. J Pept Res 52: 229-240.

A. Schulz, S. Escher, U.C. Marx, M. Meyer, P. Rösch, W.G. Forssmann, K. Adermann. (1998) Carboxy-terminal extension stabilizes the topological stereoisomers of guanylin. J Pept Res 52: 518-525.

1997

J. Klodt, M. Kuhn, U.C. Marx, S. Martin, P. Rösch, W.G. Forssmann, K. Adermann. (1997) Synthesis, biological activity and isomerism of guanylate cyclase C-activating peptides guanylin and uroguanylin. J Pept Res 50: 222-230.

1995

U.C. Marx, S. Austermann, P. Bayer, K. Adermann, A. Ejchart, H. Sticht, S. Walter, F.X. Schmid, R. Jaenicke, W.G. Forssmann, P. Rösch. (1995) Structure of human parathyroid hormone 1-37 in solution. J Biol Chem 270: 15194-15202.